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Minipress is in a class of drugs called alpha-adrenergic blockers.

Minipress is used to treat hypertension (high blood pressure). Minipress is effective used alone or with other high blood pressure medications such as diuretics or beta-blocking medications (drugs that ease heart contractions) such as Tenormin.

Minipress is also prescribed for the treatment of benign prostatic hyperplasia (BPH), an abnormal enlargement of the prostate gland.

Minipress causes the blood vessels (veins and arteries) to relax and expand, which allows blood to pass more easily through them.
Minipress contains the active ingredient prazosin hydrochloride, which is a type of medicine called an alpha-blocker. Minipress works by blocking alpha-receptors in certain areas of the body.

Alpha-receptors are present on the muscle in the walls of blood vessels. When these receptors are blocked by Minipress, the muscle relaxes, causing the blood vessels to widen. The result of this is a lowering of blood pressure and Minipress can therefore be used to treat high blood pressure.

Widening of the blood vessels also decreases the effort required by the heart to pump blood around the body, as there is less resistance. This can help treat heart failure, where the pumping action of the heart has become less effective.

Minipress can also be used to treat Raynauds disease, where the blood vessels of the hands become narrowed, resulting in cold, painful hands. Widening of the blood vessels increases the blood flow to the extremities and relieves this pain.

Alpha-receptors are also present on the muscle in the prostate gland. This gland is found only in men and lies at the top of the tube connecting the bladder to the outside (urethra). The prostate gland often enlarges with advancing age (benign prostatic hyperplasia) and can cause urinary symptoms such as poor flow of urine. By blocking the alpha-receptors, Minipress causes the muscle in the prostate to relax. This allows urine to flow freely past the prostate and relieves the urinary symptoms.

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Check your blood pressure regularly. Ask your prescriber or health care professional what your blood pressure should be and when you should contact him or her.

You may feel drowsy or dizzy. Do not drive, use machinery, or do anything that requires mental alertness until you know how prazosin affects you. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly. Avoid alcoholic drinks; they can make you more drowsy, and can increase flushing and rapid heartbeats. Taking initial doses of prazosin at bedtime can lessen the effects of drowsiness and dizziness, but be careful if you have to get up during the night. Drowsiness and dizziness are more likely to occur after the first dose, after an increase in dose, or during hot weather or exercise. These effects can decrease once your body adjusts to this medicine.

Although extremely rare in men taking prazosin, contact you health care provider immediately if you experience prolonged and painful erection of the penis which is unrelated to sexual activity (priapism). If not brought to immediate medical attention, priapism can lead to permanent erectile dysfunction (impotence).

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water, will help.

Do not take nonprescription medicine for weight-loss without asking your prescriber or health care professional. Also, do not take cough and cold, hay fever or sinus medications without asking your prescriber or health care professional.

If you are going to have surgery, tell your prescriber or health care professional that you are taking prazosin.
What side effects may I notice from this medicine?

Side effects that you should report to your prescriber or health care professional as soon as possible:

difficulty breathing, shortness of breath
prolonged painful erection of the penis (priapism)
blurred vision
fainting spells, lightheadedness
irregular heartbeat, palpitations or chest pain
mental depression
swelling of the legs and ankles
vomiting

Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):

constipation or diarrhea
drowsiness or dizziness
dry mouth
headache
nausea
sexual difficulties (impotence)
stomach pain
unusual weakness or tiredness

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What is this medicine?

PRAZOSIN is an antihypertensive. Prazosin lowers, but does not cure, high blood pressure. It works by relaxing the blood vessels. Prazosin is sometimes used for prostate problems. What should my health care professional know before I take this medicine?

They need to know if you have any of the following conditions:

angina
kidney disease
an unusual or allergic reaction to prazosin, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
breast-feeding

How should I take this medicine?

Take prazosin by mouth. Swallow the tablet with a drink of water. Taking the tablet with food can help to reduce side effects. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your prescriber's advice.
Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others. What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medicine?

Do not take prazosin if you are taking the following medications:

other alpha-blockers such as alfuzosin, doxazosin, phentolamine, phenoxybenzamine, tamsulosin, terazosin

Prazosin may also interact with the following medications:

medicines for colds and breathing difficulties
medicines for high blood pressure
monoamine oxidase inhibitors
sildenafil (doses of sildenafil higher than 25 mg should be taken at least 4 hours apart from taking prazosin)
tadalafil
vardenafil
water pills

Tell your prescriber or health care professional about all other medicines you are taking, including nonprescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your prescriber or health care professional before stopping or starting any of your medicines.